|
|
L-glutamate + 7,8-dihydropteroate + ATP <=> H+ + 7,8-dihydrofolate + phosphate + ADP
|
6.3.2.12
dihydrofolate synthase
6.3.2.17
tetrahydrofolate synthase
|
–
–
|
| |
BRENDA:
BR104
KEGG:
R02237
MetaCyc:
DIHYDROFOLATESYNTH-RXN
|
|
|
|
4-amino-4-deoxychorismate <=> H+ + 4-Aminobenzoic_acid + pyruvate
|
4.1.3.38
aminodeoxychorismate lyase
|
–
|
| |
BRENDA:
BR47975
KEGG:
R05553
MetaCyc:
ADCLY-RXN
|
|
|
|
tetrahydro-L-threo-neopterin + NADP+ <=> H+ + 7,8-dihydro-L-monapterin + NADPH
|
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
|
| |
BRENDA:
BR51347
KEGG:
R11019
MetaCyc:
RXN0-6367
|
|
|
|
7,8-dihydroneopterin_3''-triphosphate + H2O <=> 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + tripolyphosphate + H+
|
4.1.2.50
6-carboxytetrahydropterin synthase
|
–
|
| |
BRENDA:
BR50066
KEGG:
R09959
MetaCyc:
RXN0-5507
|
|
|
|
H+ + 6-carboxy-5,6,7,8-tetrahydropterin <=> 7-carboxy-7-carbaguanine + NH3
|
4.3.99.3
7-carboxy-7-deazaguanine synthase
|
–
|
| |
BRENDA:
BR50129
KEGG:
R10002
MetaCyc:
RXN0-6575
|
|
|
|
7-carboxy-7-carbaguanine + NH3 + ATP <=> H+ + 7-cyano-7-carbaguanine + ADP + phosphate + H2O
|
6.3.4.20
7-cyano-7-deazaguanine synthase
|
–
|
| |
BRENDA:
BR50022
KEGG:
R09978
MetaCyc:
RXN-12093
|
|
|
|
5-methyltetrahydrofolate + NADP+ <=> 5,10-methylenetetrahydrofolate + NADPH + H+
|
1.5.1.20
methylenetetrahydrofolate reductase [NAD(P)H]
|
–
|
| |
BRENDA:
BR36896
KEGG:
R01224
SABIO-RK:
1453
|
|
|
|
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
–
–
|
| |
BRENDA:
BR36900
KEGG:
R00939
MetaCyc:
DIHYDROFOLATEREDUCT-RXN;
RXN-19329
|
|
|
|
7,8-dihydroneopterin_3''-triphosphate <=> 7,8-dihydromonapterin_3'-triphosphate
|
5.1.99.7
dihydroneopterin triphosphate 2'-epimerase
5.1.99.8
7,8-dihydroneopterin epimerase
|
–
–
|
| |
BRENDA:
BR51427
KEGG:
R11082
MetaCyc:
H2NTPEPIM-RXN
|
|
|
|
GTP + H2O <=> H+ + formate + 7,8-dihydroneopterin_3''-triphosphate
|
3.5.4.16
GTP cyclohydrolase I
|
–
|
| |
BRENDA:
BR22737
KEGG:
R00424
MetaCyc:
GTP-CYCLOHYDRO-I-RXN
SABIO-RK:
9177
|
|
|
|
ATP + 5-formyltetrahydrofolate <=> ADP + phosphate + 5,10-methylenetetrahydrofolate
|
6.3.3.2
5-formyltetrahydrofolate cyclo-ligase
|
–
|
| |
BRENDA:
BS638
|
|
|
|
chorismate + L-glutamine <=> 4-amino-4-deoxychorismate + L-glutamate
|
2.6.1.85
aminodeoxychorismate synthase
|
–
|
| |
BRENDA:
BR47979
KEGG:
R01716
MetaCyc:
PABASYN-RXN
SABIO-RK:
1828
|
|
|
|
10-formyltetrahydrofolate + beta-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide + H+
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
| |
BRENDA:
BR43941
KEGG:
R04325
MetaCyc:
GART-RXN
|
|
|
|
10-formyltetrahydrofolate + H2O <=> tetrahydrofolate + formate + H+
|
3.5.1.10
formyltetrahydrofolate deformylase
|
–
|
| |
BRENDA:
BR22680
KEGG:
R00944
MetaCyc:
FORMYLTHFDEFORMYL-RXN
SABIO-RK:
1259
|
|
